Acyl bromides
Cayman Chemical QX314 bromide Other Receptor
A membrane-impermeant lidocaine derivative that when combined with capsaicin selectively blocks sodium channels on nociceptive neurons via the TRPV1 channel; decreases the pain response without imparting numbness or paralysis associated with other local anesthetics
Apexbio Technology LLC Ipratropium Bromide 22254-24-6 10mM (in 1mL DMSO)
Ipratropium bromide (CAS 22254-24-6) is a synthetic quaternary ammonium compound structurally derived from atropine It functions as a muscarinic acetylcholine receptor (mAChR) antagonist primarily inhibiting M3 receptor-mediated bronchoconstriction in airway smooth muscle By blocking parasympathetic-mediated bronchial smooth muscle contraction it induces bronchodilation Ipratropium bromide is widely utilized in research to investigate cholinergic signaling pathways airway physiology and the pharmacological modulation of bronchomotor tone Its properties make it valuable for studies focused on obstructive pulmonary conditions and respiratory drug development
Apexbio Technology LLC Umeclidinium bromide 869113-09-7 5mg
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Apexbio Technology LLC Umeclidinium bromide 869113-09-7 50mg
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Cayman Chemical N4-benzoyl-CytIdIn 250g
A benzyolated derivative of cytidine; a substrate of UCK1 and UCK2; has been used in the synthesis of 2ʹ-OH protecting groups for solid-phase RNA synthesis and synthetic oligonucleotides for UV light-induced and targeted gene silencing in zebrafish embryos